Date

January 10, 2025

Time

10:10 am

Location

ESC 2144

Seminar speaker: Trisha Wittkopp, U Michigan

Dr. Wittkopp’s lab:  https://sites.lsa.umich.edu/wittkopp-lab/

Abstract for seminar:

Genetic variation affecting gene expression is wide-spread within and among species. This variation reflects the combined actions of mutation introducing new genetic variants and selection eliminating deleterious ones. Comparative studies of gene expression in fruit flies, yeast, plants, and mice have shown that the relative contributions of cis- and trans-acting variants to expression differences change over evolutionary time, indicating that selection has different effects on cis- and trans-regulatory variants. To better understand the reasons for this now widely observed pattern, we have been systematically studying the effects of mutation and selection on expression of the TDH3 gene of the baker’s yeast Saccharomyces cerevisiae. This work has revealed differences between cis- and trans-regulatory mutations in their frequency, effects, and dominance. Differences in pleiotropy are also generally assumed to exist between cis- and trans-regulatory that affect their evolutionary fate, but have been difficult to measure. We have also examined how changes in the environment affect the function and fitness of regulatory variants. In this talk, I will discuss our latest findings from this line of work.